Multitrait and multipopulation QTL search using selective genotyping
نویسندگان
چکیده
منابع مشابه
A selective genotyping approach identifies QTL in a simulated population
BACKGROUND Identification of QTLs for important phenotypic traits, through the use of medium-density genome-wide SNP panels, is one of the most challenging areas in animal genetics, for preventing the time-consuming direct sequencing of putative candidate genes, when searching for the mutations that affect the trait. Appropriate statistical analyses allow the identification of genomic regions a...
متن کاملEfficient detection of QTL with large effects in a simulated pig-type pedigree using selective genotyping
BACKGROUND The ultimate goal of QTL studies is to find causative mutations, which requires additional expression studies. Given the limited amount of time and funds, the smart option is to identify the most important QTL with minimal effort. A cost-effective solution is to genotype only those animals with high or low phenotypic values or DNA-pools of these individuals. A two-stage genotyping st...
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Multiparent Advanced Generation Inter-Cross (MAGIC) populations are now being utilized to more accurately identify the underlying genetic basis of quantitative traits through quantitative trait loci (QTL) analyses and subsequent gene discovery. The expanded genetic diversity present in such populations and the amplified number of recombination events mean that QTL can be identified at a higher ...
متن کاملA new simple method for improving QTL mapping under selective genotyping.
The selective genotyping approach, where only individuals from the high and low extremes of the trait distribution are selected for genotyping and the remaining individuals are not genotyped, has been known as a cost-saving strategy to reduce genotyping work and can still maintain nearly equivalent efficiency to complete genotyping in QTL mapping. We propose a novel and simple statistical metho...
متن کاملPower calculations for selective genotyping in QTL mapping in backcross mice.
Selective genotyping concerns the genotyping of a portion of individuals chosen on the basis of their phenotypic values. Often individuals are selected for genotyping from the high and low extremes of the phenotypic distribution. This procedure yields savings in cost and time by decreasing the total number of individuals genotyped. Previous work by Darvasi et al. (1993) has shown that the power...
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ژورنال
عنوان ژورنال: Genetical Research
سال: 1997
ISSN: 0016-6723,1469-5073
DOI: 10.1017/s0016672397003030